Published on Tue Feb 25 2020

Study protocol for a multicenter randomized controlled trial to compare the efficacy of end-ischemic dual hypothermic oxygenated machine perfusion with static cold storage in preventing non-anastomotic biliary strictures after transplantation of liver grafts donated after circulatory death: DHOPE-DCD trial.

Rianne van Rijn, Aad P van den Berg, Joris I Erdmann, Nigel Heaton, Bart van Hoek, Jeroen de Jonge, Henri G D Leuvenink, Shekar V K Mahesh, Sarah Mertens, Diethard Monbaliu, Paolo Muiesan, M Thamara P R Perera, Wojciech G Polak, Xavier Rogiers, Roberto I Troisi, Yvonne de Vries, Robert J Porte

Major concern in liver transplantation of grafts from donation after circulatory death (DCD) donors remains the high incidence of non-anastomotic biliary strictures (NAS) Machine perfusion has been proposed as an alternative strategy for organ preservation.

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Abstract

The major concern in liver transplantation of grafts from donation after circulatory death (DCD) donors remains the high incidence of non-anastomotic biliary strictures (NAS). Machine perfusion has been proposed as an alternative strategy for organ preservation which reduces ischemia-reperfusion injury (IRI). Experimental studies have shown that dual hypothermic oxygenated machine perfusion (DHOPE) is associated with less IRI, improved hepatocellular function, and better preserved mitochondrial and endothelial function compared to conventional static cold storage (SCS). Moreover, DHOPE was safely applied with promising results in a recently performed phase-1 study. The aim of the current study is to determine the efficacy of DHOPE in reducing the incidence of NAS after DCD liver transplantation.