Published on Sat Aug 07 2021

The efficacy and safety of metformin alone or as an add-on therapy to insulin in pregnancy with GDM or T2DM: A systematic review and meta-analysis of 21 randomized controlled trials.

Ke He, Qing Guo, Jun Ge, Jingxin Li, Caixia Li, Zeng Jing

Metformin has been found to exhibit maternal to foetal transfer. Long-term influence of metformin on foetuses is uncertain.

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Abstract

Pregnant women are increasingly being exposed to metformin for conditions including gestational diabetes mellitus and type 2 diabetes mellitus. Metformin has been found to exhibit maternal to foetal transfer, and the long-term influence is uncertain. We conducted a meta-analysis to compare the efficacy and safety of metformin alone or as add-on therapy to insulin and insulin in pregnancy with gestational diabetes mellitus or type 2 diabetes mellitus.