Published on Sat Aug 14 2021

Proteome and functional decline as platelets age in the circulation.

Harriet E Allan, Melissa A Hayman, Simone Marcone, Melissa V Chan, Matthew L Edin, Tania Maffucci, Abhishek Joshi, Laura Menke, Marilena Crescente, Manuel Mayr, Darryl C Zeldin, Paul C Armstrong, Timothy D Warner

Platelets circulate in the blood of healthy individuals for approximately 7-10 days regulated by finely balanced processes of production and destruction. As platelets are anucleate we reasoned that their protein composition would change as they age and that this change would be linked to alterations in structure and function.

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Abstract

Platelets circulate in the blood of healthy individuals for approximately 7-10 days regulated by finely balanced processes of production and destruction. As platelets are anucleate we reasoned that their protein composition would change as they age and that this change would be linked to alterations in structure and function.