Published on Tue Jul 27 2021

Protecting Stem Cell Derived Pancreatic Beta-Like Cells From Diabetogenic T Cell Recognition.

Roberto Castro-Gutierrez, Aimon Alkanani, Clayton E Mathews, Aaron Michels, Holger A Russ

Transplantation of stem cell derived beta-like cells (sBC) has been shown to rescue diabetes in preclinical animal models. How sBC will respond to an inflammatory environment with diabetogenic T cells in a strict human setting has not been determined.

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Abstract

Type 1 diabetes results from an autoimmune attack directed at pancreatic beta cells predominantly mediated by T cells. Transplantation of stem cell derived beta-like cells (sBC) have been shown to rescue diabetes in preclinical animal models. However, how sBC will respond to an inflammatory environment with diabetogenic T cells in a strict human setting has not been determined. This is due to the lack of model systems that closely recapitulates human T1D. Here, we present a reliable