Published on Thu Jun 17 2021

Antidotal Sodium Bicarbonate Therapy: Delayed QTc Prolongation and Cardiovascular Events.

Siri Shastry, Judson Ellis, George Loo, Rajesh Vedanthan, Lynne D Richardson, Alex F Manini

Sodium bicarbonate therapy (SBT) is currently indicated for the management of a variety of acute drug poisonings. SBT effects on serum potassium concentrations may lead to delayed QTc prolongation and subsequent risk of adverse cardiovascular events (ACVE), including death.

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Abstract

Sodium bicarbonate therapy (SBT) is currently indicated for the management of a variety of acute drug poisonings. However, SBT effects on serum potassium concentrations may lead to delayed QTc prolongation (DQTP), and subsequent risk of adverse cardiovascular events (ACVE), including death. Emergency department (ED)-based studies evaluating associations between SBT and ACVE are limited; thus, we aimed to investigate the association between antidotal SBT, ECG changes, and ACVE.