Published on Sun Jun 06 2021

Skeletal Muscle Function Is Dependent Upon BRCA1 to Maintain Genomic Stability.

Michael D Tarpey, Adam J Amorese, Elizabeth R LaFave, Everett C Minchew, Kelsey H Fisher-Wellman, Joseph M McClung, Eli G Hvastkovs, Espen E Spangenburg

Breast Cancer gene 1 (BRCA1) is a large, multi-functional protein that regulates a variety of mechanisms in multiple different tissues. Brca1 is expressed in skeletal muscle and localizes to the mitochondria and nucleus.

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Abstract

Breast Cancer gene 1 (BRCA1) is a large, multi-functional protein that regulates a variety of mechanisms in multiple different tissues. Our work established that Brca1 is expressed in skeletal muscle and localizes to the mitochondria and nucleus. Here, we propose BRCA1 expression is critical for the maintenance of force production and mitochondrial respiration in skeletal muscle.