Published on Tue Nov 13 2018

Prognostic Gleason grade grouping: data based on the modified Gleason scoring system.

Phillip M Pierorazio, Patrick C Walsh, Alan W Partin, Jonathan I Epstein

The Gleason scoring system is a well-established predictor of pathological stage and oncological outcomes. Modifications throughout the last few decades have attempted to improve the correlation between biopsy and radical prostatectomy Gleason sum.

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Abstract

WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: The Gleason scoring system is a well-established predictor of pathological stage and oncological outcomes for men with prostate cancer. Modifications throughout the last few decades - most recently by the International Society of Urological Pathology (ISUP) in 2005 - have attempted to improve the correlation between biopsy and radical prostatectomy Gleason sum and better stratify patients to predict clinical outcomes. Based on these clinical outcomes and the excellent prognosis for patients with low Gleason scores, we recommend Gleason grades incorporating a prognostic grade grouping which accurately reflect prognosis and are clearly understood by physicians and patients alike.