Published on Tue Aug 24 2021

Outdoor air pollution and terminal duct lobular involution of the normal breast.

Nicole M Niehoff, Alexander P Keil, Rena R Jones, Shaoqi Fan, Gretchen L Gierach, Alexandra J White

Exposure to certain outdoor air pollutants may be associated with a higher risk of breast cancer, though potential underlying mechanisms are poorly understood. We examined whether outdoor air pollution was associated with involution of terminal duct lobular units (TDLUs), the histologic site where most cancers arise and an intermediate marker of breast cancer risk.