Published on Wed Sep 22 2021

Diagnostic accuracy of the Cepheid 3-gene host response fingerstick blood test in a prospective, multi-site study: interim results.

Jayne S Sutherland, Gian van der Spuy, Awa Gindeh, Nguyen Thuy Thuong, Ann Ritah Namuganga, Olumuyiwa Owolabi, Harriet Mayanja-Kizza, Mary Nsereko, Guy Thwaites, Jill Winter, Hazel M Dockrell, Thomas J Scriba, Annemieke Geluk, Paul Corstjens, Kim Stanley, Tracy Richardson, Jane A Shaw, Bronwyn Smith, Stephanus T Malherbe, Gerhard Walzl

The development of a fast and accurate, non-sputum-based point-of-care triage test for tuberculosis would have a major impact on combating the TB burden worldwide.

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Abstract

The development of a fast and accurate, non-sputum-based point-of-care triage test for tuberculosis (TB) would have a major impact on combating the TB burden worldwide. A new fingerstick blood test has been developed by Cepheid (the Xpert-MTB-Host Response (HR)-Prototype), which generates a 'TB score' based on mRNA expression of 3 genes. Here we describe the first prospective findings of the MTB-HR prototype.