Published on Sun May 12 2019

Prolonged half-life of verapamil in a case of overdose: implications for therapy.

C D Buckley, J K Aronson

After an overdose of verapamil (2.4 g) in a 59-year-old man the apparent half-life of verAPamil was prolonged (15 h) The most likely mechanism is rate-limiting absorption.

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Abstract

After an overdose of verapamil (2.4 g) in a 59-year-old man the apparent half-life of verapamil was prolonged (15 h). The most likely mechanism is rate-limiting absorption, although changes in clearance and volume of distribution may contribute. As the elimination half-life of verapamil is increased in overdose, therapy may have to be continued for longer than expected. Moreover since the half-life of absorption of verapamil in overdose may be prolonged, activated charcoal should be given in repeated doses, even if an ordinary-release formulation has been taken.