Major Outcomes With Personalized Dialysate TEMPerature (MyTEMP): Rationale and Design of a Pragmatic, Registry-Based, Cluster Randomized Controlled Trial.
Ahmed A Al-Jaishi, Christopher W McIntyre, Jessica M Sontrop, Stephanie N Dixon, Sierra Anderson, Amit Bagga, Derek Benjamin, David Berry, Peter G Blake, Laura Chambers, Patricia C K Chan, Nicole Delbrouck, P J Devereaux, Luis F Ferreira-Divino, Richard Goluch, Laura Gregor, Jeremy M Grimshaw, Garth Hanson, Eduard Iliescu, Arsh K Jain, Charmaine E Lok, Reem A Mustafa, Bharat Nathoo, Gihad E Nesrallah, Matthew J Oliver, Sanjay Pandeya, Malvinder S Parmar, David Perkins, Justin Presseau, Eli Rabin, Joanna Sasal, Tanya Shulman, Manish M Sood, Andrew Steele, Paul Tam, Daniel Tascona, Davinder Wadehra, Ron Wald, Michael Walsh, Paul Watson, Walter Wodchis, Phillip Zager, Merrick Zwarenstein, Amit X Garg
Small randomized trials demonstrated that a lower compared with higher dialysate temperature reduced the average drop in intradialytic blood pressure. Some observational studies demonstrated that a lower compared with higher dialysate temperature was associated with a lower risk of all-cause mortality and cardiovascular mortality. There is now the need for a large randomized trial that compares the effect of a low vs high dialysate temperature on major cardiovascular outcomes.